누리사이언스

As companion animals are recognized as family members, their struggle against diseases agonize the people around them.
Diseases of companion animals have various fields including tumor.
Due to the longer life expectancy of companion animals, the onset rate of cancers is increasing.
Approximately 64% of disease cases of companion animals is dermatitis.
Currently, most of the disease cases are being treated with human therapeutics.
Therefore, development of therapeutics for companion animals is urgent and important.

Market Size of Global Animal Cancer Therapeutics

Common Diseases of Companion Animals

Canine breast cancer is one of the most common cancers found in female dogs, showing over 75% among cancer cases.
Approximately 45% of mammary gland tumor develops to malignant tumor, making it a high-risk disease.
The disease is multiple and highly metastatic, caused by sex hormones or genetic factors.
Operations and chemical treatments are available, but surgical removal is adopted in most of the cases.
Demands for painless, novel treatment technologies via non-incisive method are increasing as well.
Currently, anticancer drugs for breast cancers that utilize safe and highly effective antibody proteins are actively in use.
However, research for such antibody protein therapeutics that can be used for companion animals is not taking place and consequently, only chemical anticancer drugs are in use.

Tissue Staining for Canine Breast Cancer

Breast
Cancer Tissue

Tumor Cells bound with Breast Cancer
-Targeting Therapeutics

The antibody protein for breast cancer treatment specifically binds to cancer cells only.
The antibody therapeutics do not possess any kind of side effects which chemical anticancer agents show;
they remove only tumor cells by using the effects of dog immune cells (NK cells) and immune proteins (complements).

Treatment Method of Breast Cancer-Targeting Antibody

Unlike humans, dogs’ skin does not have any sweat glands and the epidermic layer is thin, which causes a high onset rate of skin diseases (itchiness, dermatitis).
Epidermic cells are made of keratinous cells produced from skin keratinous stem cells, and endodermic tissues have natural immune cells to defend the body.
Dermatitis is caused by bacterial and germ infection, which reduces the functionality of skin immune cells and results in diseases.
Allergic dermatitis is caused by various factors such as foods, pollens, and fibers.

Physiological Efficacy of Skin Disease Therapeutic Proteins

The proteins recover damaged skin (injuries, itchiness) by regenerating new epidermic skin through the induction of dog skin keratinous stem cell activation.
By facilitating the production of skin immune cell-activating proteins, the proteins activate the functionalities of immune cells and express various dermatitis treatment and prevention efficacies.

Companion Animal Disease Treatment